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KMID : 0357919820160010043
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Korean Journal of Pathology
1982 Volume.16 No. 1 p.43 ~ p.51
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An Experimental Study on the Changes of Serum Lipids in Rabbits with the Posthemorrhagic Anemia
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김진규(金辰圭):Kim Jin-Q
저자없음:No authors listed
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Abstract
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Serum liplds were estimated in 17 healthy rabbits as a control group and 9 rabbits
with the experimentally induced posthemorrhagic anemia. Anemia was incuced in rabbits
by serial phlebotomy with the three to four days interval. At each time of the
phlebotomy, about ten percent of the total blood volume was drawn out from the rabbits
and the phlebotomy was performed six titles during the study. The anemic group
consisted of low hemoglobin group and low hematocrit group compared with the control
group. Both the anemic groups of the rabbits had low serum lipids levels with a mean
of 57 to 87 percent of the controls. A positive correlation was established in male
anemic rabbits for hemoglobin and hematocrit with the HDL-Cholesterol, Cholesterol,
Total lipid and phospholipid, but not with Triglycerides. Female anemic rabbits remarked
the positive correlation only with the Cholesterol. The correlation of reticulocytes
production wilt the decrease of the serutm lipids was not significant in statistics. This
study shows the correlation of hematocrit decrease and hypocholesterolemia was more
significant than that of the hemoglobin and hypocholesterolemia. In conclusion, plasma
dilutional effect was considered to be an of the most plausible explanations as the
mechanism of the hypolipidemia accompanying anemia, however, there may be several
other contributory factors with complexities that should to studied.
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KEYWORD
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